Strongly Bent Double-Stranded DNA: Reconciling Theory and Experiment
نویسندگان
چکیده
منابع مشابه
Polyamines preferentially interact with bent adenine tracts in double-stranded DNA
Polyamines, such as putrescine, spermidine and spermine, have indirectly been linked with the regulation of gene expression, and their concentrations are typically increased in cancer cells. Although effects on transcription factor binding to cognate DNA targets have been demonstrated, the mechanisms of the biological action of polyamines is poorly understood. Employing uranyl photo-probing we ...
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It is suggested that computations using DNA molecules as computing units may sometimes be simpler to carry out and less error prone if double stranded DNA molecules are used rather than the single stranded molecules currently being used. A detailed illustration is given of a biomolecular algorithm that uses double stranded DNA for the solution of the directed Hamiltonian path problem.
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RNA plays myriad roles in the transmission and regulation of genetic information that are fundamentally constrained by its mechanical properties, including the elasticity and conformational transitions of the double-stranded (dsRNA) form. Although double-stranded DNA (dsDNA) mechanics have been dissected with exquisite precision, much less is known about dsRNA. Here we present a comprehensive c...
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ژورنال
عنوان ژورنال: Frontiers in Physics
سال: 2019
ISSN: 2296-424X
DOI: 10.3389/fphy.2019.00195